�We�ve seen with genetics that cancers can be targeted based on whether certain mutations are present, and it could be that selectively targeting tumors based on their metabolism could have a similar impact�
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| Koningic acid, a potent selective GAPDH inhibitor, for metabolic research |
Source/Credit: RT News
By RT News | September 15, 2017
The Warburg effect has varying levels of influence in cancers
Cancer�s energy source can be thwarted by a naturally-occurring molecule which stops affected cells from consuming sugar, according to a new study.
Koningic acid (KA) was found to disrupt the metabolism of cancerous cells.
Published in Cell Metabolism the team from Duke Cancer Institute in North Carolina first set out to study the �Warburg effect,� a known but little understood process in which cancer cells modify their metabolism to consume glucose for energy production.
The team compared stages of the Warburg effect to that of normal cell activity. An enzyme known as Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was found to control the rate of glucose processing in cancer cells.
Researchers tested koningic against GAPDH and discovered how to successfully curb its glucose consumption in mouse models. Normal cells were not affected by the introduction of the molecule.
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Eye on health: Starve cancer of energy with natural molecule, study advises
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